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About 50% of Americans suffer from hemorrhoids at some point during their life. Over 10% of American adults (or 22 million people) have experienced hemorrhoids during the past year. Close to 3% (or 6.7 million people) suffer from it on any given day. This is a very active patient population with 85% of them using treatment, mostly in the form of over-the-counter (OTC) or prescription drugs. American consumers spend over $400 million each year on OTC hemorrhoid treatment products. Prescription drugs are also used (often off label) to treat hemorrhoids: about 2-4 million prescriptions per year are filled with a total value of $43M.